Modafinil and HIV
Modafinil is a wakefulness-promoting psychostimulant used to treat excessive drowsiness in adults caused by narcolepsy, sleep apnea, or shift work disorder. Modafinil functions by influencing the neurotransmitters in the brain.
HIV is a virus that attacks the immune system, which is responsible for fighting infections and diseases when it enters the body. HIV is incurable, but it is certainly treatable.
Although clinical researchers are unsure as to why HIV can cause fatigue, a few plausible causes have been linked to it. As it is well known that HIV is a long-term, chronic disease and that the mere presence of a virus causes the body to exert a strong immune response, which requires constant energy, HIV is a significant energy drain. Where the viral load is undetectable, even low-level HIV-induced inflammation can consume a great deal of energy.
Even when health is largely stable or improved due to antiretroviral treatment, fatigue continues to be a major issue for many HIV-positive individuals. HIV and AIDS patients who are contemplating a return to work face a formidable obstacle in the form of fatigue, which is linked to disability and lower life satisfaction. Previously, fatigue was attributed to the virus and its associated infections; however, it now appears that antiretroviral drugs also play a role.